Sonderforschungsbreich 35

Transmembrane Transporters
in Health and Disease

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2017


 

Anderluh A, Hofmaier T, Klotzsch E, Kudlacek O, Stockner T, Sitte HH, Schütz GJ.

Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter.

Nat Commun. 2017 Jan 19;8:14089. doi: 10.1038/ncomms14089.

 

Kern C, Erdem FA, El-Kasaby A, Sandtner W, Freissmuth M, Sucic S.

The N-terminus specifies the switch between transport modes of the human serotonin transporter.

J Biol Chem. 2017 Jan 19. pii: jbc.M116.771360. doi: 10.1074/jbc.M116.771360. [Epub ahead of print]

 

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

Occupancy of the Zinc Binding-site by Transition Metals decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism.

J Biol Chem. 2017 Jan 17. pii: jbc.M116.760140. doi: 10.1074/jbc.M116.760140. [Epub ahead of print]

 

Kotsampasakou E, Escher SE, Ecker GF.

Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case.

Eur J Pharm Sci. 2017 Jan 4;100:9-16. doi: 10.1016/j.ejps.2017.01.002.

http://dx.doi.org/10.1016/j.ejps.2017.01.002

 

Arab JP, Karpen SJ, Dawson PA, Arrese M, Trauner M.

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives.

Hepatology. 2017 Jan;65(1):350-362. doi: 10.1002/hep.28709. Epub 2016 Aug 4.

 

Fuchs CD, Paumgartner G, Wahlström A, Schwabl P, Reiberger T, Leditznig N, Stojakovic T, Rohr-Udilova N, Chiba P, Marschall HU, Trauner M.

Metabolic preconditioning protects BSEP/ABCB11-/- mice against cholestatic liver injury.

J Hepatol. 2017 Jan;66(1):95-101. doi: 10.1016/j.jhep.2016.08.017. Epub 2016 Sep 1.

 

Sauerzopf U, Sacco R, Novarino G, Niello M, Weidenauer A, Praschak-Rieder N, Sitte H, Willeit M.

Are reprogrammed cells a useful tool for studying dopamine dysfunction in psychotic disorders? A review of the current evidence.

Eur J Neurosci. 2017 Jan;45(1):45-57. doi: 10.1111/ejn.13418. Review.

 


2016


 

Mayer FP, Luf A, Nagy C, Holy M, Schmid R, Freissmuth M, Sitte HH.

Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters.

Curr Top Behav Neurosci. 2016 Dec 27. doi: 10.1007/7854_2016_63. [Epub ahead of print]

 

Lemberger UJ, Fuchs CD, Karer M, Haas S, Stojakovic T, Schöfer C, Marschall HU, Wrba F, Taketo MM, Egger G, Trauner M, Österreicher CH.

Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease.

Oncotarget. 2016 Dec 27;7(52):86985-86998. doi: 10.18632/oncotarget.13521.

 

Trauner M, Fuchs CD, Halilbasic E, Paumgartner G.

New therapeutic concepts in bile acid transport and signaling for management of cholestasis.

Hepatology. 2016 Dec 20. doi: 10.1002/hep.28991. [Epub ahead of print]

 

Schwabl P, Hambruch E, Seeland BA, Hayden H, Wagner M, Garnys L, Strobel B, Schubert TL, Riedl F, Mittereger D, Burnet M, Starlinger P, Oberhuber G, Deuschle U, Rohr-Udilova N, Podesser BK, Peck-Radosavljevic M, Reiberger T, Kremoser C, Trauner M.

The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction.

J Hepatol. 2016 Dec 16. pii: S0168-8278(16)30710-3. doi: 10.1016/j.jhep.2016.12.005. [Epub ahead of print]

 

Hasenhuetl PS, Freissmuth M, Sandtner W.

Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter.

J Biol Chem. 2016 Dec 9;291(50):25864-25876.

 

Tărlungeanu DC, Deliu E, Dotter CP, Kara M, Janiesch PC, Scalise M, Galluccio M, Tesulov M, Morelli E, Sonmez FM, Bilguvar K, Ohgaki R, Kanai Y, Johansen A, Esharif S, Ben-Omran T, Topcu M, Schlessinger A, Indiveri C, Duncan KE, Caglayan AO, Gunel M, Gleeson JG, Novarino G.

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.

Cell. 2016 Dec 1;167(6):1481-1494.e18. doi: 10.1016/j.cell.2016.11.013.

 

Szöllősi D, Chiba P, Szakács G, Stockner T, Hegedűs T.

Mechanism of drug transport by ABC multidrug proteins in structural perspectives

Royal Society Of Chemistry: Amino Acids, Peptides and Proteins, Volume 41, 2017, Pages 152-187;
Print ISBN: 978-1-78262-537-7; PDF eISBN: 978-1-78262-661-9; EPUB eISBN: 978-1-78801-081-8;
DOI: 10.1039/9781782626619

 

Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T.

The Environment Shapes the Inner Vestibule of LeuT.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005197. doi: 10.1371/journal.pcbi.1005197.

 

Seddik A, Geerke DP, Stockner T, Holy M, Kudlacek O, Cozzi NV, Ruoho AE, Sitte HH, Ecker GF.

Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter.

Mol Inform. 2016 Nov 8. doi: 10.1002/minf.201600094.

published online Nov 8; http://dx.doi.org/10.1002/minf.201600094

 

Fuchs CD, Schwabl P, Reiberger T, Trauner M.

Liver Capsule: FXR agonists against liver disease.

Hepatology. 2016 Nov;64(5):1773. doi: 10.1002/hep.28836. No abstract available. Erratum in: Hepatology. 2017 Jan;65(1):397

 

Venkatesan S, Saha K, Sohail A, Sandtner W, Freissmuth M, Ecker GF, Sitte HH, Stockner T.

Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site.

PLoS Comput Biol. 2015 Oct 20;11(10):e1004551. doi: 10.1371/journal.pcbi.1004551.

 

Bauer M, Karch R, Tournier N, Cisternino S, Wadsak W, Hacker M, Marhofer P, Zeitlinger M, Langer O.

Assessment of P-glycoprotein Transport Activity at the Human Blood-Retinal Barrier with (R)-11C-verapamil PET

J Nucl Med. 2016 Oct 13. pii: jnumed.116.182147.

 

Billesbølle CB, Mortensen JS, Sohail A, Schmidt SG, Shi L, Sitte HH, Gether U, Loland CJ.

Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter.

Nat Commun. 2016 Sep 28;7:12755. doi: 10.1038/ncomms12755.

 

Zdrazil B, Hellsberg E, Viereck M, Ecker GF

From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter.

Medchemcomm. 2016 Sep 14;7(9):1819-1831. Epub 2016 Jul 22.

 

Mayer FP, Wimmer L, Dillon-Carter O, Partilla JS, Burchardt NV, Mihovilovic MD, Baumann MH, Sitte HH.

Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters.

Br J Pharmacol. 2016 Sep;173(17):2657-68. doi: 10.1111/bph.13547.

 

Tournier N, Goutal S, Auvity S, Traxl A, Mairinger S, Wanek T, Helal OB, Buvat I, Soussan M, Caillé F, Langer O.

Strategies to inhibit ABCB1- and ABCG2-mediated efflux transport of erlotinib at the blood-brain barrier: a PET study in non-human primates.

J Nucl Med. 2016 Aug 4. pii: jnumed.116.178665.

 

Kasture A, El-Kasaby A, Szöllősi D, Asjad HM, Grimm A, Stockner T, Hummel T, Freissmuth M, Sucic S.

Functional rescue of a misfolded Drosophila melanogaster dopamine transporter mutant associated with a sleepless phenotype by pharmacological chaperones.

J Biol Chem. 2016 Aug 1. pii: jbc.M116.737551. [Epub ahead of print]

 

Zhu C, Fuchs CD, Halilbasic E, Trauner M.

Bile acids in regulation of inflammation and immunity: friend or foe?

Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl 98):25-31. Review

 

Montanari F, Cseke A, Wlcek K, Ecker GF.

Virtual Screening of DrugBank Reveals Two Drugs as New BCRP Inhibitors.

J Biomol Screen. 2016 Jul 8. pii: 1087057116657513. [Epub ahead of print]

 

Halilbasic E, Fuchs C, Traussnigg S, Trauner M.

Farnesoid X Receptor Agonists and Other Bile Acid Signaling Strategies for Treatment of Liver Disease.

Dig Dis. 2016;34(5):580-8. doi: 10.1159/000445268. Epub 2016 Jun 22.

 

Schwarz T, Montanari F, Cseke A, Wlcek K, Visvader L, Palme S, Chiba P, Kuchler K, Urban E, Ecker GF.

Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).

ChemMedChem. 2016 Jun 20;11(12):1380-94. doi: 10.1002/cmdc.201500592. Epub 2016 Mar 10.

 

Dallas S, Salphati L, Gomez-Zepeda D, Wanek T, Chen L, Chu X, Kunta J, Mezler M, Menet MC, Chasseigneaux S, Decleves X, Langer O, Pierre E, DiLoreto K, Hoft C, Laplanche L, Pang J, Pereira T, Andonian C, Simic D, Rode A, Yabut J, Zhang X, Scheer N

Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.

Mol Pharmacol. 2016 May;89(5):492-504. doi: 10.1124/mol.115.102079. Epub 2016 Feb 18.

 

Bauer M, Blaickner M, Philippe C, Wadsak W, Hacker M, Zeitlinger M, Langer O.

Whole-body Distribution and Radiation Dosimetry of 11C-Elacridar and 11C-Tariquidar in Humans.

J Nucl Med. 2016 Apr 14. pii: jnumed.116.175182.

 

Bársony O, Szalóki G, Türk D, Tarapcsák S, Gutay-Tóth Z, Bacsó Z, Holb IJ, Székvölgyi L, Szabó G, Csanády L, Szakács G, Goda K.

A single active catalytic site is sufficient to promote transport in P-glycoprotein.

Sci Rep. 2016 Apr 27;6:24810. doi: 10.1038/srep24810.

 

Wagner M, Trauner M.

Recent advances in understanding and managing cholestasis.

F1000Res. 2016 Apr 19;5. pii: F1000 Faculty Rev-705. doi: 10.12688/f1000research.8012.1. eCollection 2016.

 

Sase A, Aher YD, Saroja SR, Ganesan MK, Sase S, Holy M, Höger H, Bakulev V, Ecker GF, Langer T, Sitte HH, Leban J, Lubec G.

A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes.

Neuropharmacology. 2016 Mar;102:186-96. doi: 10.1016/j.neuropharm.2015.07.039.

 

Baghdasaryan A, Fuchs CD, Österreicher CH, Lemberger UJ, Halilbasic E, Påhlman I, Graffner H, Krones E, Fickert P, Wahlström A, Ståhlman M, Paumgartner G, Marschall HU, Trauner M.

Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.

Hepatol. 2016 Mar;64(3):674-81. doi: 10.1016/j.jhep.2015.10.024. Epub 2015 Oct 31. pii: S0168-8278(15)00723-0

 

Bauer M, Römermann K, Karch R, Wulkersdorfer B, Stanek J, Philippe C, Maier-Salamon A, Haslacher H, Jungbauer C, Wadsak W, Jäger W, Löscher W, Hacker M, Zeitlinger M, Langer O.

A pilot PET study to assess the functional interplay between ABCB1 and ABCG2 at the human blood-brain barrier

Clin Pharmacol Ther. 2016 Mar 3. doi: 10.1002/cpt.362.

 

Montanari F, Zdrazil B, Digles D, Ecker GF.

Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning.

J Cheminform. 2016 Feb 4;8:7. doi: 10.1186/s13321-016-0121-y. eCollection 2016.

 

Fuchs CD, Traussnigg SA, Trauner M.

Nuclear Receptor Modulation for the Treatment of Nonalcoholic Fatty Liver Disease.

Semin Liver Dis. 2016 Feb;36(1):69-86. doi: 10.1055/s-0036-1571296. Epub 2016 Feb 12.

 

Wanek T, Halilbasic E, Visentin M, Mairinger S, Römermann K, Stieger B, Kuntner C, Müller M, Langer O, Trauner M.

Influence of 24-Nor-Ursodeoxycholic Acid on Hepatic Disposition of [(18)F]Ciprofloxacin, a Positron Emission Tomography Study in Mice.

J Pharm Sci. 2016 Jan;105(1):106-12. doi: 10.1016/j.xphs.2015.11.014. Epub 2016 Jan 13.

 

Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, Hauck Newman A, Sitte HH, Hinterdorfer P.

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

Angew Chem Int Ed Engl. 2016 Jan;55(5):1719-22. doi: 10.1002/anie.201508755. Epub 2015 Dec 22.

 

Montanari F, Pinto M, Khunweeraphong N, Wlcek K, Sohail MI, Noeske T, Boyer S, Chiba P, Stieger B, Kuchler K, Ecker GF.

Flagging Drugs That Inhibit the Bile Salt Export Pump.

Mol Pharm. 2016 Jan 4;13(1):163-71. doi: 10.1021/acs.molpharmaceut.5b00594. Epub 2015 Dec 21.

 

Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang Y, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH.

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters.

Mol Pharmacol. 2016 Jan;89(1):165-75. doi: 10.1124/mol.115.101394. Epub 2015 Oct 30.

 

Meyer BM, Huemer J, Rabl U, Boubela RN, Kalcher K, Berger A, Banaschewski T, Barker G, Bokde A, Büchel C, Conrod P, Desrivières S, Flor H, Frouin V, Gallinat J, Garavan H, Heinz A, Ittermann B, Jia T, Lathrop M, Martinot JL, Nees F, Rietschel M, Smolka MN, Bartova L, Popovic A, Scharinger C, Sitte HH, Steiner H, Friedrich MH, Kasper S, Perkmann T, Praschak-Rieder N, Haslacher H, Esterbauer H, Moser E, Schumann G, Pezawas L.

Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

Brain Struct Funct. 2016 Jan; 221: 103–114. Published online 2014 Oct 16. doi: 10.1007/s00429-014-0895-5

 


2015


 

Komposch K, Sibilia M.

EGFR Signaling in Liver Diseases.

Int J Mol Sci. 2015 Dec 29;17(1). pii: E30. doi: 10.3390/ijms17010030. Review

 

Traxl A, Wanek T, Mairinger S, Stanek J, Filip T, Sauberer M, Müller M, Kuntner C, Langer O.

Breast Cancer Resistance Protein and P-glycoprotein Influence In Vivo Disposition of 11C-Erlotinib.

J Nucl Med. 2015 Dec;56(12):1930-6. doi: 10.2967/jnumed.115.161273. Epub 2015 Sep 10.

 

Halilbasic E, Fuchs C, Hofer H, Paumgartner G, Trauner M.

Therapy of Primary Sclerosing Cholangitis--Today and Tomorrow

Dig Dis. 2015;33 Suppl 2:149-63. doi: 10.1159/000440827. Epub 2015 Dec 7.

 

Gergely Szakács, Tamás Hegedűs, Balázs Sarkadi

Inborn Errors of the Cellular Expression and Localization of ABCG2 and ABCB6. A Database for ABC Transporter Mutations

Springer International Publishing ABC Transporters - 40 Years on, pp 341-355, ISBN: 978-3-319-23475-5 (Print) 978-3-319-23476-2 (Online), doi: 10.1007/978-3-319-23476-2_14, 2015 Dec 17

 

Kotsampasakou E, Brenner S, Jäger W, Ecker GF. 

Identification of Novel Inhibitors of Organic Anion Transporting Polypeptides 1B1 and 1B3 (OATP1B1 and OATP1B3) Using a Consensus Vote of Six Classification Models.

Mol Pharm. 2015 Dec 7;12(12):4395-404. doi: 10.1021/acs.molpharmaceut.5b00583. Epub 2015 Nov 2.

 

Li Y, Hasenhuetl PS, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter.

J Biol Chem. 2015 Dec 25;290(52):31069-76. doi: 10.1074/jbc.M115.688275. Epub 2015 Oct 26.

 

Venkatesan S, Saha K, Sohail A, Sandtner W, Freissmuth M, Ecker GF, Sitte HH, Stockner T.

Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site.

PLoS Comput Biol. 2015 Oct 20;11(10):e1004551. doi: 10.1371/journal.pcbi.1004551. eCollection 2015 Oct.

 

Stockner T, Mullen A, MacMillan F.

Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applications.

Biochem Soc Trans. 2015 Oct 1;43(5):1023-32. doi: 10.1042/BST20150138.

 

Schmid D, Koenig X, Bulusu S, Schicker K, Freissmuth M, Sitte HH, Sandtner W.

The conservative view: is it necessary to implant a stent into the dopamine transporter?

Br J Pharmacol. 2015 Oct;172(19):4775-8. doi: 10.1111/bph.12766. No abstract available.

 

Wanek T, Römermann K, Mairinger S, Stanek J, Sauberer M, Filip T, Traxl A, Kuntner C, Pahnke J, Bauer F, Erker T, Löscher W, Müller M, Langer O.

Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography.

Mol Pharm. 2015 Sep 8;12(9):3214-25. doi: 10.1021/acs.molpharmaceut.5b00168. Epub 2015 Aug 3.

 

Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W.

Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.

Mol Pharmacol. 2015 Jul;88(1):12-8. doi: 10.1124/mol.115.099036. Epub 2015 Apr 14.

 

Wanek T, Traxl A, Bankstahl JP, Bankstahl M, Sauberer M, Langer O, Kuntner C.

[18F]FDG is not transported by P-glycoprotein and breast cancer resistance protein at the rodent blood-brain barrier.

Nucl Med Biol. 2015 Jul;42(7):585-9. doi: 10.1016/j.nucmedbio.2015.03.004. Epub 2015 Mar 18

 

Mueller M, Thorell A, Claudel T, Jha P, Koefeler H, Lackner C, Hoesel B, Fauler G, Stojakovic T, Einarsson C, Marschall HU, Trauner M.

Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity.

J Hepatol. 2015 Jun;62(6):1398-404. doi: 10.1016/j.jhep.2014.12.034. Epub 2015 Jan 21.

 

Montanari F, Ecker GF.

Prediction of drug-ABC-transporter interaction--Recent advances and future challenges.

Adv Drug Deliv Rev.2015 Jun 23;86:17-26. doi: 10.1016/j.addr.2015.03.001. Epub 2015 Mar 11. Review.

 

Boubela RN, Kalcher K, Huf W, Seidel EM, Derntl B, Pezawas L, Našel C, Moser E.

fMRI measurements of amygdala activation are confounded by stimulus correlated signal fluctuation in nearby veins draining distant brain regions.

Sci Rep. 2015 May 21;5:10499. doi: 10.1038/srep10499.

 

Bartova L, Meyer BM, Diers K, Rabl U, Scharinger C, Popovic A, Pail G, Kalcher K, Boubela RN, Huemer J, Mandorfer D, Windischberger C, Sitte HH, Kasper S, Praschak-Rieder N, Moser E, Brocke B, Pezawas L.

Reduced default mode network suppression during a working memory task in remitted major depression.

J Psychiatr Res. 2015 May;64:9-18. doi: 10.1016/j.jpsychires.2015.02.025. Epub 2015 Mar 6.

 

Stanek J, Mairinger S, Wanek T, Kuntner C, Müller M, Langer O.

Automated radiosynthesis of [(18)F]ciprofloxacin.

Appl Radiat Isot. 2015 May;99:133-7. doi: 10.1016/j.apradiso.2015.02.024. Epub 2015 Feb 27.

 

Koban F, El-Kasaby A, Häusler C, Stockner T, Simbrunner BM, Sitte HH, Freissmuth M, Sucic S

A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.

J Biol Chem. 2015 May 22;290(21):13263-78. doi: 10.1074/jbc.M115.641357. Epub 2015 Apr 13.

 

Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH.

Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.

J Neurosci. 2015 May 27;35(21):8258-71. doi: 10.1523/JNEUROSCI.4034-14.2015.
Erratum in: J Neurosci. 2015 Aug 19;35(33):11762.

 

Saha K, Partilla JS, Lehner KR, Seddik A, Stockner T, Holy M, Sandtner W, Ecker GF, Sitte HH, Baumann MH.

'Second-Generation' Mephedrone Analogs, 4-MEC and 4-MePPP, Differentially Affect Monoamine Transporter Function

Neuropsychopharmacology. 2015 May;40(6):1321-31. doi: 10.1038/npp.2014.325. Epub 2014 Dec 15.

 

Trauner M, Halilbasic E, Claudel T, Steinacher D, Fuchs C, Moustafa T, Pollheimer M, Krones E, Kienbacher C, Traussnigg S, Kazemi-Shirazi L, Munda P, Hofer H, Fickert P, Paumgartner G.

Potential of nor-Ursodeoxycholic Acid in Cholestatic and Metabolic Disorders.

Dig Dis. 2015;33(3):433-9. doi: 10.1159/000371904. Epub 2015 May 27. Review.

 

Krones E, Wagner M, Eller K, Rosenkranz AR, Trauner M, Fickert P.

Bile acid-induced cholemic nephropathy.

Dig Dis. 2015;33(3):367-75. doi: 10.1159/000371689. Epub 2015 May 27. Review.

 

Sitte HH, Schütz GJ, Freissmuth M.

Cooperativity between individual transporter protomers: new data fuelling old complexes.

J Neurochem. 2015 Apr;133(2):163-6. doi: 10.1111/jnc.13086. Epub 2015 Mar 15.

 

Kiss K, Kucsma N, Brozik A, Tusnady GE, Bergam P, van Niel G, Szakacs G.

Role of the N-terminal transmembrane domain in the endo-lysosomal targeting and function of the human ABCB6 protein.

Biochem J. 2015 Apr 1;467(1):127-39. doi: 10.1042/BJ20141085.

 

Beuers U, Trauner M, Jansen P, Poupon R.

New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond.

J Hepatol. 2015 Apr;62(1 Suppl):S25-37. doi: 10.1016/j.jhep.2015.02.023. Review

 

Hellsberg E, Montanari F, Ecker GF.

The ABC of Phytohormone Translocation.

Planta Med. 2015 Apr;81(6):474-87. doi: 10.1055/s-0035-1545880. Epub 2015 Apr 23. Review.

 

Jurik A, Zdrazil B, Holy M, Stockner T, Sitte HH, Ecker GF.

A Binding Mode Hypothesis of Tiagabine Confirms Liothyronine Effect on γ-Aminobutyric Acid Transporter 1 (GAT1).

J Med Chem. 2015 Mar 12;58(5):2149-58. doi: 10.1021/jm5015428. Epub 2015 Feb 26.

 

Kong E, Sucic S, Monje FJ, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD.

STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior.

Sci Rep. 2015 Mar 11;5:9009. doi: 10.1038/srep09009.

 

Neudorfer C, Seddik A, Shanab K, Jurik A, Rami-Mark C, Holzer W, Ecker G, Mitterhauser M, Wadsak W, Spreitzer H.

Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter

Molecules. 2015 Jan 20;20(1):1712-30. doi: 10.3390/molecules20011712.

 

Bauer M, Karch R, Zeitlinger M, Philippe C, Römermann K, Stanek J, Maier-Salamon A, Wadsak W, Jäger W, Hacker M, Müller M, Langer O

Approaching complete inhibition of P-glycoprotein at the human blood-brain barrier: an (R)-[11C]verapamil PET study

In press_J Cereb Blood Flow Metab (2015) doi:10.1038/jcbfm.2015.19

 

Klotzsch E, Smorodchenko A, Löfler L, Moldzio R, Parkinson E, Schütz GJ, Pohl EE

Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):130-5. doi: 10.1073/pnas.1415261112. Epub 2014 Dec 22.

 

Sitte HH, Freissmuth M.

Amphetamines, new psychoactive drugs and the monoamine transporter cycle

Trends Pharmacol Sci. 2015 Jan;36(1):41-50. doi: 10.1016/j.tips.2014.11.006. Epub 2014 Dec 23.

 

 


2014


 

Anderluh A, Klotzsch E, Reismann AW, Brameshuber M, Kudlacek O, Newman AH, Sitte HH, Schütz GJ.

Single Molecule Analysis Reveals Coexistence of Stable Serotonin Transporter Monomers and Oligomers in the Live Cell Plasma Membrane.

J Biol Chem. 2014 Feb 14;289(7):4387-94. doi: 10.1074/jbc.M113.531632. Epub 2014 Jan 6.

 

Anderluh A, Klotzsch E, Ries J, Reismann AW, Weber S1 Fölser M, Koban F, Freissmuth M, Sitte HH, Schütz GJ

Tracking single serotonin transporter molecules at the endoplasmic reticulum and plasma membrane

Biophys J. 2014 May 6;106(9):L33-5. doi: 10.1016/j.bpj.2014.03.019

 

Bankstahl JP

What does a picture tell? In vivo imaging of ABC transporter function

Drug Discov Today Technol. 2014 Jun;12:e113-9. doi: 10.1016/j.ddtec.2014.03.014.

 

Baghdasaryan A, Chiba P, Trauner M

Clinical application of transcriptional activators of bile salt transporters

Mol Aspects Med. 2014 Jun;37C:57-76. doi: 10.1016/j.mam.2013.12.001. Epub 2013 Dec 12.

 

Bauer M, Karch R, Zeitlinger M , Liu J, Koepp MJ, Asselin MC, Sisodiya SM, Hainfellner JA, Wadsak W, Mitterhauser M, Müller M, Pataraia E, Langer O.

In-vivo P-glycoprotein function before and after epilepsy surgery

Neurology. 2014 Sep 3. pii: 10.1212/WNL.0000000000000858.Epub 2014 Sep 3.

 

Baumann MH, Bulling S, Benaderet TS, Saha K, Ayestas MA, Partilla JS, Ali SF, Stockner T, Rothman RB, Sandtner W, Sitte HH

Evidence for a Role of Transporter-Mediated Currents in the Depletion of Brain Serotonin Induced by Serotonin Transporter Substrates

Neuropsychopharmacology, 2014 May;39(6):1355-65. doi: 10.1038/npp.2013.331. Epub 2013 Nov 28.

 

Chiba P, Freissmuth M, Stockner T.

Defining the blanks - Pharmacochaperoning of SLC6 transporters and ABC transporters

Pharmacol Res. 2014 May;83:63-73. doi: 10.1016/j.phrs.2013.11.009. Epub 2013 Dec 6.

 

Cuperus FJC, Claudel T, Gautherot J, Halilbasic E, Trauner M.

The role of canalicular ABC transporters in cholestasis

Drug Metab Dispos. 2014 Apr;42(4):546-60. doi: 10.1124/dmd.113.056358. Epub 2014 Jan 28.

 

Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Theurl I, Theurl M, Seifert M, Lener D, Stanzl U, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Moschen AR, Li X, Pallweber P, Scharnagl H, Stojakovic T, März W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge UJ, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, Tancevski I.

The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.

Cell Metab. 2014 Nov 4;20(5):787-98.

 

Donmez Cakil Y, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P.

Pore Exposed Tyrosine Residues of P-glycoprotein are Important Hydrogen Bonding Partners for Drugs.

Mol Pharmacol. 2014 Mar;85(3):420-8. doi: 10.1124/mol.113.088526. Epub 2013 Dec 23.

 

Ecker GF, Jurik A, Seddik A, Zdrazil B, Stockner T, Freissmuth M, Sitte HH

Modelling to identify substrate recognition sites of neurotransmitter transporters. In: "Methods to Investigate Neurotransmitter Transporters"

NEUROMETHODS series, Springer Publishing group, Editors: Bönisch H. and Sitte H.H., 2014

 

El-Kasaby A, Koban F, Sitte HH, Freissmuth M, Sucic S.

A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter

J Biol Chem. 2014 Oct 17;289(42):28987-9000. doi: 10.1074/jbc.M114.595090. Epub 2014 Sep 8.

 

Felts B, Pramod AB, Sandtner W, Burbach N, Bulling S, Sitte HH, Henry LK.

The Two Na+ Sites in the Human Serotonin Transporter Play Distinct Roles in the Ion Coupling and Electrogenicity of Transport.

J Biol Chem. 2014 Jan 17;289(3):1825-40. doi: 10.1074/jbc.M113.504654. Epub 2013 Nov 29.

 

Fenollar-Ferrer C, Stockner T, Schwarz TC, Pal A, Gotovina J, Hofmaier T, Jayaraman K, Adhikary S, Kudlacek O, Mehdipour AR, Tavoulari S, Rudnick G, Singh SK, Konrat R, Sitte HH, Forrest LR.

Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.

Biochemistry. 2014 Aug 26;53(33):5444-60. doi: 10.1021/bi500637f. Epub 2014 Aug 15.

 

Fuchs CD, Claudel T, Trauner M.

Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD.

Trends Endocrinol Metab. 2014 Nov;25(11):576-85. doi: 10.1016/j.tem.2014.08.001. Epub 2014 Aug 30.

 

Goldmann D, Montanari F, Richter L, Zdrazil B, Ecker GF

Exploiting open data:a new era in pharmacoinformatics.

Future Med Chem. 2014 Apr;6(5):503-14. doi:10.4155/fmc.14.13.

 

Griesauer I, Diao W, Ronovsky M, Elbau I, Sartori S, Singewald N, Pollak DD.

Circadian abnormalities in a mouse model of high trait anxiety and depression.

Ann Med. 2014 May;46(3):148-54. doi: 10.3109/07853890.2013.866440. Epub 2014 Jan 10.

 

Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, Law I, Pinborg LH, Sitte HH, Loland C, Shi L, Weinstein H, Galli A, Hjermind LE, Møller LB, Gether U.

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD

J Clin Invest. 2014 Jul;124(7):3107-20. doi: 10.1172/JCI73778.

 

Hofmaier T, Luf A, Seddik A, Stockner T, Holy M, Freissmuth M, Ecker GF, Schmid R, Sitte HH, Kudlacek O

Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters.

Neurochem Int. 2014 Jul;73:32-41. doi: 10.1016/j.neuint.2013.11.010. Epub 2013 Dec 1.

 

Kalcher K, Boubela RN, Huf W, Bartova L, Kronnerwetter C, Derntl B, Pezawas L, Filzmoser P, Nasel C, Moser E.

The spectral diversity of resting-state fluctuations in the human brain

PLoS One. 2014 Apr 11;9(4):e93375. doi:10.1371/journal.pone.0093375. eCollection 2014.

 

Khan D, Fernando P, Cicvaric A, Berger A, Pollak A, Monje FJ, Pollak DD

Long-term effects of maternal immune activation on depression-like behavior in the mouse

Transl Psychiatry. 2014 Feb 18;4:e363. doi: 10.1038/tp.2013.132.

 

Khan D, Savalli G, Ronovsky M, Freissmuth M, Sitte HH, Pollak DD

Animal models for depression and the mode of action of neurotransmitter transporter-blocking antidepressants

In: "Methods to Investigate Neurotransmitter Transporters", NEUROMETHODS series, Springer Publishing group, Editors: Bönisch H. and Sitte H.H., 2014

 

Kong E, Monje FJ, Hirsch J, Pollak DD

Learning not to Fear: Neural Correlates of Learned Safety

Neuropsychopharmacology. 2014 Feb;39(3):515-27. doi: 10.1038/npp.2013.191. Epub 2013 Aug 21.

 

Lanaya H, Natarajan A, Komposch K, Li L, Amberg N, Chen L, Wculek SK, Hammer M, Zenz R, Peck-Radosavljevic M, Sieghart W, Trauner M, Wang H, Sibilia M.

EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation.

Nat Cell Biol. 2014 Oct;16(10):972-81, 1-7. doi: 10.1038/ncb3031. Epub 2014 Aug 31.

 

Langer O.

PET imaging of ABC transporters at the blood-brain barrier

In: Methods and Principles in Medicinal Chemistry - Transporters as Drug Targets. Editors: Gerhard F. Ecker, Rasmus Clausen and Harald Sitte, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany

 

Michl J, Scharinger C, Zauner M, Kasper S, Freissmuth M, Sitte HH, Ecker GF, Pezawas L.

A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities.

Eur Neuropsychopharmacol. 2014 Sep;24(9):1463-74. doi: 10.1016/j.euroneuro.2014.06.013. Epub 2014 Jul 3.

 

Montanari F, Ecker GF

BCRP inhibition - from data collection to ligand-based modeling

Mol Inform, 2014

 

Montgomery TR, Steinkellner T, Sucic S, Koban F, Schüchner S, Ogris E, Sitte HH, Freissmuth M

Axonal Targeting of the Serotonin Transporter in Cultured Rat Dorsal Raphe Neurons Is Specified by SEC24C-Dependent Export from the Endoplasmic Reticulum

J Neurosci. 2014 Apr 30;34(18):6344-51. doi: 10.1523/ JNEUROSCI.2991-13.2014.

 

Parveen Z, Brunhofer G, Jabeen I, Erker T, Chiba P, Ecker GF

Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein

Bioorg Med Chem. 2014 Apr 1;22(7):2311-9. doi: 10.1016/j.bmc.2014.02.005. Epub 2014 Feb 15.

 

Pinto M, Digles D, Ecker GF

Computational Models for predicting the interaction with ABC-transporter

Drug Discov Today Technol. 2014 Jun;12:e69-77. doi: 10.1016/j.ddtec.2014.03.007. No abstract available.

 

Pollak DD, Minh BQ, Cicvaric A, Monje FJ.

A novel fibroblast growth factor receptor family member promotes neuronal outgrowth and synaptic plasticity in aplysia.

Amino Acids. 2014 Nov;46(11):2477-88. doi: 10.1007/s00726-014-1803-2. Epub 2014 Jul 25.

 

Rabl U, Meyer B, Diers K, Bartova L, Berger A, Mandorfer D, Popovic A, Scharinger C, Huemer J, Kalcher K, Pail G, Haslacher H, Perkmann T, Windischberger C, Brocke B, Sitte HH, Pollak DD, Dreher JC, Kasper S, Praschak-Rieder N, Moser E, Esterbauer H, Pezawas L

Additive Gene-Environment Effects on Hippocampal Structure in Healthy Humans

J Neurosci. 2014 Jul 23;34(30):9917-26. doi: 10.1523/JNEUROSCI.3113-13.2014.

 

Rudashevskaya EL, Stockner T, Trauner M, Freissmuth M, Chiba P

Pharmacological correction of misfolding of ABC proteins

Drug Discov Today Technol. 2014 Jun;12:e87-94. doi: 10.1016/j.ddtec.2014.03.009. No abstract available. (Review)

 

Sandtner W, Schmid D, Schicker K, Gerstbrein K, Koenig X, Mayer F, Boehm S, Freissmuth M, Sitte HH

A Quantitative Model of Amphetamine Action on the Serotonin Transporter

Br J Pharmacol. 2014 Feb;171(4):1007-18. doi: 10.1111/bph.12520.

 

Savalli G, Diao W, Schulz S, Todtova K, Pollak DD.

Diurnal oscillation of amygdala clock gene expression and loss of synchrony in a mouse model of depression.

Int J Neuropsychopharmacol. 2014 Dec 11;18(5). pii: pyu095. doi: 10.1093/ijnp/pyu095.

 

Schaap FG, Trauner M, Jansen PL.

Bile acid receptors as targets for drug development.

Nat Rev Gastroenterol Hepatol. 2014 Jan;11(1):55-67. doi: 10.1038/nrgastro.2013.151. Epub 2013 Aug 27. Review

 

Scharinger C, Rabl U, Kasess CH, Meyer BM, Hofmaier T, Diers K, Bartova L, Pail G, Huf W, Uzelac Z, Hartiner B, Kalcher K, Perkmann T, Haslacher H, Meyer-Lindenberg A, Kasper S, Freissmuth M, Windischberger C, Willeit M, Lanzenberger R, Esterbauer H, Brocke B, Moser E, Sitte HH, Pezawas L.

Platelet serotonin transporter function predicts default-mode network activity

PLoS One. 2014 Mar 25;9(3):e92543.B137

 

Sitte HH, Stockner T, Ecker GF, Freissmuth M.

Molecular basis of drug/transporter interaction "Transporters as Drug Targets"

Wiley-VCH, Editors: Ecker G.F., Clausen R.P., Sitte H.H.

 

Sombetzki M, Fuchs CD, Fickert P, Österreicher CH, Mueller M, Claudel T, Loebermann M, Engelmann R, Langner C, Sahin E, Schwinge D, Guenther ND, Schramm C, Mueller-Hilke B, Reisinger EC, Trauner M.

24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis.

J Hepatol. 2015 Apr;62(4):871-8. doi: 10.1016/j.jhep.2014.11.020. Epub 2014 Nov 21.

 

Steinkellner T, Holy M, Freissmuth M, Sitte HH

Tracer measurements to study outward transport by neurotransmitter transporters. In: "Methods to Investigate Neurotransmitter Transporters"

NEUROMETHODS series, Springer Publishing group, Editors: Bönisch H. and Sitte H.H., 2014

 

Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova EV, Kong E, Willeit M, Sotnikova TD, Kudlacek O, Gether U, Freissmuth M, Pollak DD, Gainetdinov RR, Sitte HH

In vivo Amphetamine, Action is Contingent on αCaMKII

Neuropsychopharmacology. 2014 Oct;39(11):2681-93. doi: 10.1038/npp.2014.124. Epub 2014 May 29.

 

Stiedl P, McMahon R, Blaas L, Stanek V, Svinka J, Grabner B, Zollner G, Kessler SM, Claudel T, Müller M, Mikulits W, Bilban M, Esterbauer H, Eferl R, Haybaeck J, Trauner M, Casanova E.

Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis.

Hepatology. 2015 Feb;61(2):613-26. doi: 10.1002/hep.27408.

 

Stieger B, Unadkat JD, Prasad B, Langer O, Gali H.

Role of (drug) transporters in imaging in health and disease

Drug Metab Dispos. 2014 Dec;42(12):2007-15. doi: 10.1124/dmd.114.059873. Epub 2014 Sep 23.

 

Stockner T, Freissmuth M, Ecker GF, Sitte HH.

Development of refined homology models of medically relevant neurotransmitter transporters: adding the missing information

In: "Membrane transporter function: to structure and beyond", Springer Series in Biophysics: Transporters. Eds.: Krämer R. and Ziegler C., 2014

 

Trauner M, Halilbasic E, Kazemi-Shirazi L, Kienbacher C, Staufer K, Traussnigg S, Hofer H.

Therapeutic role of bile acids and nuclear receptor agonists in fibrosing cholangiopathies.

Dig Dis. 2014;32(5):631-6. doi: 10.1159/000360517. Epub 2014 Jul 14.

 

Viereck M, Gaulton A, Digles D, Ecker GF

Transporter taxonomy – a comparison of different transport protein classification schemes

Drug Discovery Today: Technologies 2014

 

Woolbright BL, Li F, Xie Y, Farhood A, Fickert P, Trauner M, Jaeschke H.

Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice

Toxicol Lett.3;228(1):56-66, 2014

 

Wulkersdorfer B, Wanek T, Bauer M, Zeitlinger M, Müller M, Langer O.

Using positron emission tomography to study transporter-mediated drug-drug interactions in tissues.

Clin Pharmacol Ther. 2014 Aug;96(2):206-13. doi: 10.1038/clpt.2014.70. Epub 2014 Mar 28.

 

Zdrazil B, Chichester C, Zander Balderud L, Engkvist O, Gaulton A, Overington JP

Transporter assays and assay ontologies: useful tools for drug discovery

Drug Discovery Today: Technologies, 2014

 

Zhang J, Chtcheglova LA, Zhu R, Hinterdorfer P, Tang J, Zhang B

Nano-scale Organization of Human GnRH-R on Human Bladder Cancer Cells

Anal Chem. 2014 Mar 4;86(5):2458-64. doi: 10.1021/ac403304g. Epub 2014 Feb 11.

 

Zhu R, Duman M, Madl J, Schütz GJ, Hinterdorfer P.

Chapter 16 Combined Topography, Recognition, and Fluorescence Measurements on Cells. Cell Membrane Nanodomains: From Biochemistry to Nanoscopy,

367-390, ISBN-13:978-1-4822-0989-1, CRC Press. (2014)




2013


 

Bankstahl JP, Bankstahl M, Römermann K, Wanek T, Stanek J, Windhorst AD, Fedrowitz M, Erker T, Müller M, Löscher W, Langer O, Kuntner C.

Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal PET and in-vitro study

Drug Metabol Dispos (2013) Apr;41(4):754-62. doi: 10.1124/dmd.112.049148. Epub 2013 Jan 10.

 

Bauer M, Zeitlinger M, Todorut D, Böhmdorfer M, Müller M, Langer O, Jäger W.

Pharmacokinetics of single ascending doses of the P-glycoprotein inhibitor tariquidar in healthy subjects

Pharmacology, 2013;91(1-2):12-9. doi: 10.1159/000343243. Epub 2012 Nov 7

 

Bauer M, Karch R, Zeitlinger M, Stanek J, Philippe C, Wadsak W, Mitterhauser M, Jäger W, Haslacher H, Müller M, Langer O.

Interaction of 11C-tariquidar and 11C-elacridar with P-glycoprotein and breast cancer resistance protein at the human blood-brain barrier

J Nucl Med. 2013 Aug;54(8):1181-7. doi: 10.2967/jnumed.112.118232. Epub 2013 Jul 5.

 

Buchmayer F, Schicker K, Steinkellner T, Geier P, Stübiger G, Hamilton PJ, Jurik A, Stockner T, Yang JW, Montgomery T, Holy M, Hofmaier T, Kudlacek O, Matthies HJ, Ecker GF, Bochkov V, Galli A, Boehm S, Sitte HH.

Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11642-7. doi: 10.1073/pnas.1220552110. Epub 2013 Jun 24.

 

Cozzi NV, Brandt SD, Daley PF, Partilla JS, Rothman RB, Tulzer A, Sitte HH, Baumann MH.

Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs.

Eur J Pharmacol. 2013 Jan 15;699(1-3):180-7. doi: 10.1016/j.ejphar.2012.11.008. Epub 2012 Nov 21.

 

Halilbasic E, Baghdasaryan A, Trauner M.

Nuclear receptors as drug targets in cholestatic liver diseases

Clin Liver Dis. 2013 May;17(2):161-89. doi: 10.1016/j.cld.2012.12.001.

 

Hofmaier T, Luf A, Seddik A, Stockner T, Holy M, Freissmuth M, Ecker GF, Schmid R, Sitte HH, Kudlacek O.

Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters.

Neurochem Int. 2013 Dec 1. pii: S0197-0186(13)00307-0. doi: 10.1016/j.neuint.2013.11.010.

 

Jabeen I, Wetwitayaklung P, Chiba P, Pastor M, Ecker GF

2D- and 3D-QSAR studies of a series of benzopyranes and benzopyrano[3,4b][1,4]-oxazines as inhibitors of the multidrug transporter P-glycoprotein

J Comput Aided Mol Des. (2013) Feb;27(2):161-71. doi: 10.1007/s10822-013-9635-9. Epub 2013 Feb 12.

 

Jurik A, Reicherstorfer R, Zdrazil B, Ecker GF.

Classification of High-Activity Tiagabine Analogs by Binary QSAR Modeling.

Mol Inform. 2013 Jun;32(5-6):415-419. Epub 2013 May 15.

 

Pavitra Kannan, Victor W. Pike, Christer Halldin, Oliver Langer, Michael M. Gottesman, Robert B. Innis, Matthew D. Hall

Factors that limit PET imaging of P-glycoprotein density at the blood-brain barrier

Mol Pharm, (2013) Jun 3;10(6):2222-9. doi: 10.1021/mp400011g. Epub 2013 May 2.

 

Klepsch F, Poongavanam V, Ecker GF.

Ligand and structure-based classification models for Prediction of P-glycoprotein inhibitors.

J Chem Inf Model. 2013 Sep 19. [Epub ahead of print]

 

Monje FJ, Divisch I, Demit M, Lubec G, Pollak DD.

Flotillin-1 is an evolutionary-conserved memory-related protein up-regulated in implicit and explicit learning paradigms.

Ann Med. 2013 Jun;45(4):301-7. doi: 10.3109/07853890.2013.770637. Epub 2013 Apr 30.

 

Moritz AE, Foster JD, Gorentla BK, Mazei-Robison MS, Yang JW, Sitte HH, Blakely RD, Vaughan RA

Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding.

J Biol Chem. 2013 Jan 4;288(1):20-32. doi: 10.1074/jbc.M112.407874. Epub 2012 Nov 16.

 

Müllauer J, Karch R, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Mairinger S, Müller M, Löscher W, Langer O, Kuntner C.

Assessment of cerebral P-glycoprotein expression and function with PET by combined [11C]inhibitor and [11C]substrate scans in rats

Nucl Med Biol. 2013 Aug;40(6):755-63. doi: 10.1016/j.nucmedbio.2013.05.005. (2013)

 

Römermann K, Wanek T, Marion Bankstahl, Jens P Bankstahl, Maren Fedrowitz, Markus Müller, Wolfgang Löscher, Claudia Kuntner, Oliver Langer

(R)-[11C]verapamil is selectively transported by murine and human P-glycoprotein, and not MRP1 and BCRP at the blood-brain barrier

Nucl Med Biol. 2013 Jul 8. pii: S0969-8051(13)00116-9. doi: 10.1016/j.nucmedbio.2013.05.012.

 

Rosenauer R, Luf A, Holy M, Freissmuth M, Schmid R, Sitte HH

A combined approach using transporter-flux assays and mass spectrometry to examine psychostimulant street drugs of unknown content

ACS Chem Neurosci. (2013) Jan 16;4(1):182-90. doi: 10.1021/cn3001763. Epub 2012 Dec 3

 

Sandtner W, Schmid D, Schicker K, Gerstbrein K, Koenig X, Mayer F, Boehm S, Freissmuth M, Sitte HH.

A Quantitative Model of Amphetamine Action on the Serotonin Transporter.

Br J Pharmacol. 2013 Nov 20. doi: 10.1111/bph.12520. [Epub ahead of print]

 

Seddik A, Holy M, Weissensteiner R, Zdrazil B, Sitte HH, Ecker GF.

Probing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling.

Mol Inform. 2013 Jun;32(5-6):409-413. Epub 2013 Jun 12.

 

Stockner T, Montgomery TR, Kudlacek O., Weissensteiner R, Ecker GF, Freissmuth M, Sitte HH

Mutational Analysis of the High-Affinity Zinc Binding Site Validates a Refined Human Dopamine Transporter Homology Model

PLOS Computational Biology, (2013) Feb;9(2):e1002909. doi: 10.1371/journal.pcbi.1002909. Epub 2013 Feb 21.

 

Sucic S, Koban F, El-Kasaby A, Kudlacek O, Stockner T, Sitte HH, Freissmuth M.

Switching the clientele: a lysine residing in the C-terminus of the serotonin transporter specifies its preference for the COPII component SEC24C

J Biol Chem. (2013), Feb 22;288(8):5330-41. doi: 10.1074/jbc.M112.408237.

 

Werner M, Atil B, Sieczkowski E, Chiba P, Hohenegger M.

Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Jul;386(7):605-17. doi: 10.1007/s00210-013-0859-y. Epub 2013 Apr 7.

 

Zhang J, Liu H, Zhu R, Hinterdorfer P, Zhang B, Tang J.

Single molecular dissection of the ligand binding property of epidermal growth factor receptor.

Analyst. 2013 Sep 21;138(18):5325-31. doi: 10.1039/c3an00778b. Epub 2013 Jul 19.

 

Zhu R, Rupprecht A, Ebner A, Haselgrübler T, Gruber HJ, Hinterdorfer P, Pohl EE.

Mapping the nucleotide binding site of uncoupling protein 1 using atomic force microscopy.

J Am Chem Soc. 2013 Mar 6;135(9):3640-6. doi: 10.1021/ja312550k. Epub 2013 Feb 26.

 

T. Wanek, S. Mairinger, O. Langer

Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier. Special issue: Carbon-11 and fluorine-18 chemistry devoted to molecular probes for imaging the brain with PET

Journal of Labelled Compounds and Radiopharmaceuticals, Special Issue: Carbon-11 and fluorine-18 chemistry devoted to molecular probes for imaging the brain with PET, Volume 56, Issue 3-4, pages 68–77, March-April 2013

 

Müller, Markus (Ed.) (2013), Series: AAPS Advances in the Pharmaceutical Sciences Series, Vol. 4; 2013, XI, 338 p. 55 illus., 29 in color, ISBN 978-1-4614-4815-0

Microdialysis in Drug Development

 

 


2012


 

Bauer F, Wanek T, Mairinger S, Stanek J, Sauberer M, Kuntner C, Parveen Z, Chiba P, Müller M, Langer O, Erker T,

Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography

Eur J Pharmacol 696(1-3):18-27 (2012)

 

Bauer M, Zeitlinger M, Karch R, Matzneller P, Stanek J, Jäger W, Böhmdorfer M, Wadsak W, Mitterhauser M, Bankstahl JP, Löscher W, Koepp M, Müller M, Langer O

Pharmacokinetics of single ascending doses of the P-glycoprotein inhibitor tariquidar in healthy subjects

Pharmacology 91(1-2):12-19 (2012)

 

Bauer M, Zeitlinger M, Karch R, Matzneller P, Stanek J, Jäger W, Böhmdorfer M, Wadsak W, Mitterhauser M, Bankstahl JP, Löscher W, Koepp M, Müller M, Langer O

Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data.

Clin Pharmacol Ther. (2012) Feb;91(2):227-33. doi: 10.1038/clpt.2011.217.

 

Baumann MH, Partilla JS, Lehner KR, Throndike EB, Hoffman AF, Holy M, Rothman RB, Goldberg SR, Lupica CR, Sitte HH, Brandt SD, Tella SR, Cozzi NV, Schindler CW

Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive 'Bath Salts' Products.

Neuropsychopharmacology. (2012) Oct 17. doi: 10.1038/npp.2012.204

 

Brast S, Grabner A, Sucic S, Sitte HH, Hermann E, Pavenstädt H, Schlatter E, and Ciarimboli G

The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization

FASEB J, (2012) Mar;26(3):976-86.

 

Bulling S, Schicker K, Zhang YW, Steinkellner T, Stockner T, Gruber C, Boehm S, Freissmuth M, Rudnick G, Sitte HH, Sandtner W.

The mechanistic basis for non-competitive ibogaine inhibition of serotonin and dopamine transporters.

J Biol Chem. (2012) May 25;287(22):18524-34.

 

Foster JD, Yang JW, Moritz AE, Challasivakanaka S, Smith MA, Holy M, Wilebski K, Sitte HH, Vaughan RA.

Dopamine transporter phosphorylation site threonine 53 regulates substrate reuptake and amphetamine-stimulated efflux

J Biol Chem. (2012), Aug 24; 287(35):29702-12. doi: 10.1074/jbc.M112.367706.

 

Jabeen I, Pleban K, Rinner U, Chiba P, Ecker GF

Structure–Activity Relationships, Ligand Efficiency, and Lipophilic Efficiency Profiles of Benzophenone-Type Inhibitors of the Multidrug Transporter P-Glycoprotein (will be online soon)

J. Med. Chem. (2012), Article ASAP, DOI: 10.1021/jm201705f, Publication Date (Web): March 27, 2012

 

Jurik A, Klepsch F, Zdrazil B, book edited by Deniz Ekinci, ISBN 978-953-51-0513-8, Published: May 16, 2012, under CC BY 3.0 license

Molecular Modeling and Simulation of Membrane Transport Proteins, Medicinal, Chemistry and Drug Design

 

Kalcher K, Huf W, Boubela RN, Filzmoser P, Pezawas L, Biswal B, Kasper S, Moser E, Windischberger C.

Fully exploratory network independent component analysis of the 1000 functional connectomes database.

Front Hum Neurosci. (2012); 6:301. doi: 10.3389/fnhum.2012.00301

 

Mairinger S, Bankstahl JP, Kuntner C, Römermann K, Bankstahl M, Wanek T, Stanek J, Löscher W, Müller M, Erker T, Langer O

The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug resistance protein 1 at the blood-brain barrier: a positron emission tomography study

Epilepsy Res 100 (1-2):93-103 (2012)

 

Mairinger S, Wanek T, Kuntner C, Doenmez Y, Strommer S, Stanek J, Capparelli E, Chiba P, Müller M, Colabufo NA, Langer O

Synthesis and preclinical evaluation of the radiolabeled P-glycoprotein inhibitor [11C]MC113

Nucl Med Biol 39(8):1219-1225 (2012)

 

Müllauer J, Kuntner C, Bauer M, Bankstahl JP, Müller M, Langer O, Syvänen S.

Pharmacokinetic-pharmacodynamic modeling of P-glycoprotein function at the rat and human blood-brain barrier studied with (R)-[11C]verapamil positron emission tomography

Eur J Nucl Med Mol Imaging Research 2(1):58 (2012)

 

Pinto M, Trauner M, Ecker GF

An In Silico Classification Model for Putative ABCC2 Substrates

Mol Inform 31, 547-53 (2012)

 

Poongavanam V, Haider N, Ecker GF

Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors

Bioorg Med Chem 20, 5388-5395 (2012); DOI: 10.1016/j.bmc.2012.03.04

 

Schicker K, Uzelac Z, Gesmonde J, Bulling S, Stockner T, Freissmuth M, Boehm S, Rudnick G, Sitte HH, Sandtner W.

Unifying concept of serotonin transporter-associated currents

J Biol Chem. 2012 Jan 2;287(1):438-45.

 

Sieben C, Kappel C, Zhu R, Wozniak A, Rankl C, Hinterdorfer P, Grubmüller H, Herrmann A.

Influenza virus binds its host cell using multiple dynamic interactions.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13626-31. doi: 10.1073/pnas.1120265109

 

Steinkellner T, Yang JW, Montgomery TR, Chen WQ, Winkler MT, Sucic S, Lubec G, Freissmuth M, Elgersma Y, Sitte HH, Kudlacek O.

Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome

J Biol Chem. (2012) Aug 24; 287(35):29627-35. doi: 10.1074/jbc.M112.367219

 

Wanek T, Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Sauberer M, Mairinger S, Strommer S, Wacheck V, Löscher W, Erker T, Müller M, Langer O

A comparative small-animal PET evaluation of [(11)C]tariquidar, [ (11)C]elacridar and (R)-[(11)C]verapamil for detection of P-glycoprotein-expressing murine breast cancer

Eur J Nucl Med Mol Imaging. (2012) Jan;39(1):149-59.

 

Wanek T, Kuntner C, Bankstahl JP, Mairinger S, Bankstahl M, Stanek J, Sauberer M, Filip T, Erker T, Müller M, Löscher W, Langer O

A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier

J Cereb Blood Flow Metab 32(11):2002-2011 (2012)

 

Wildling L, Rankl C, Haselgruebler T, Gruber HJ, Holy M, Newman AH, Zou MF, Zhu R, Freissmuth M, Sitte HH, Hinterdorfer P

Probing the binding pocket of the serotonin transporter by single molecular force spectroscopy on living cells

J Biol Chem. (2012) Jan 2;287(1):105-13.

 


2011


Bankstahl JP, Bankstahl M, Kuntner C, Stanek J, Wanek T, Meier M, Ding X-Q, Müller M, Langer O, Löscher W

A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier

J Neurosci.; 31(24):8803-11.(2011)

 

Borecká S, Pinjon E, Sullivan DJ, Kuchler K, Blaško J, Bujdáková H.

Cdr2 contributes to fluconazole resistance in C. dubliniensis isolates

Can. J. Microbiol. 57:416-426 (2011)

 

Boubela RN, Huf W,Kalcher K, Sladky R, Filzmoser P, Pezawas L, Kasper S, Windischberger C, Moser E

A Highly Parallelized Framework for Computationally Intensive MR Data Analysis

MAGMA (2011) Nov 16.

 

Dörner B, Kuntner C, Bankstahl JP, Wanek T, Bankstahl M, Stanek J, Müllauer J, Bauer F, Mairinger S, Löscher W, Miller DW, Chiba P, Müller M, Erker T, Langer O

Radiosynthesis and in vivo evaluation of 1-[(18)F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein

Bioorg Med Chem.; 19:2190-8. (2011)

 

Jabeen I, Wetwitayaklung P, Klepsch F, Parveen Z, Chiba P, Ecker GF

Probing the stereoselectivity of P-glycoprotein – synthesis, biological activity and preliminary docking studies of a set of enantiopure benzopyrano[3,4b][1,4]oxazines

Chem Comm; 47(9) Epub 2010 Dec 21., 2586-2588 (2011)

 

Keller T, Egenberger B, Gorboulev V, Bernhard F, Uzelac Z, Gorbunov D, Wirth C, Koppatz S, Dötsch V, Hunte C, Sitte HH, Koepsell H

The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization

J Biol Chem. (2011) Oct 28;286(43):37874-86.

 

Klein C, Kuchler K, & Valachovic M

ABC proteins in yeast & fungal pathogens

Essays in Biochemistry - ABC Transporters (Guest Ed. Frances Sharom). Portland Press, London, Sep 7;50(1):101-19. (2011)

 

Klepsch F, Chiba P, Ecker GF

Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein

PLoS Comp Biol; 7(5):e1002036. Epub 2011 May 12.(2011)

 

Kuchler K.

About Multidrug Resistance and Genetic Diseases.

FEBS J. (2011) Sep;278(18):3189. doi: 10.1111/j.1742-4658.2011.08234.x. Epub 2011 Aug 1. No abstract available.

 

Kuchler K

The ABC of ABCs: multidrug resistance and genetic diseases

FEBS J. (2011) Sep;278(18):3189. doi: 10.1111/j.1742-4658.2011.08234.x. Epub 2011 Aug 1.

 

Malle E, Zhou H, Neuhold J, Spitzenberger B, Klepsch F, Pollak T, Bergner O, Ecker GF, and Stolt-Bergner PC

Random mutagenesis of the prokaryotic peptide transporter YDGR identifies potential periplasmic gating residues

J Biol Chem.; 286:23121-31, (2011)

 

Navaroli DM, Stevens ZH, Uzelac Z, Gabriel L, King MJ, Lifshitz LM, Sitte HH, Melikian HE

The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking

Neurosci. 31(39):13758-70. (2011)

 

Parveen Z, Stockner T, Bentele C, Pferschy S, Kraupp M, Freissmuth M, Ecker GF, Chiba P.

Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein

Mol Pharmacol; 79(3):443-452, (2011)

 

Rabl U, Scharinger C, Hofmaier T, Freissmuth M, Pezawas L.

Genetic regulation of emotion brain circuitries

In: López-Muñoz F, Álamo C, editors. Neurobiology of Depression. Boca Raton, USA: CRC Press.;75-95. (2011)

 

Rabl U, Pezawas L, Meyer-Lindenberg A,

Emotion and Genetics

In: Ochsner K, Kosslyn S, editors. Oxford Handbook of Cognitive Neuroscience. Oxford, UK: Oxford University Press.(2011)

 

Scharinger C, Rabl U, Pezawas L, Kasper S,

The genetic blueprint of Major Depressive Disorder: contributions of imaging genetics studies

The World Journal of Biological Psychiatry, Oct;12(7):474-88. Epub 2011 Aug 11. (2011)

 

Scharinger C, Bartova L, Pezawas L,

Brain-derived neurotrophic factor: a peripheral biomarker for major depressive disorder and antidepressant efficacy?

Personalized Medicine; 8:115-117. (2011)

 

Steinkellner T, Freissmuth M, Sitte HH, Montgomery T

The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine

Biol Chem.;392:103-15. (2011)

 

Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P, Freissmuth M

The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C

J Biol Chem; 286:16482-16490, (2011)

 

Tscherner M., Schwarzmüller T., & Kuchler K.

Pathogenesis and antifungal drug resistance of the human fungal pathogen Candida glabrata

Pharmaceuticals 4: 169-186; doi:10.3390/ph4010169 (2011)

 

Wagner CC, Simpson M, Zeitlinger M, Bauer M, Karch R, Abrahim A, Feurstein T, Schütz M, Kletter K, Müller M, Lappin G, Langer O

A combined accelerator mass spectrometry-positron emission tomography human microdose study with 14C- and 11C-labelled verapamil

Clin Pharmacokin.; 50(2):111-20. (2011)

 

Weissensteiner R, Steinkellner T, Jurik A, Bulling S, Sandtner W, Kudlacek O, Freissmuth M, Ecker GF and Sitte HH*

Towards an understanding of the psychostimulant action of amphetamine and cocaine. In: SENSORY PERCEPTION, Mind and Matter

Eds.: Barth F.G., Giamperi-Deutsch P., Klein H.-D. (2011)

 

Wildling L, Unterauer B, Zhu R, Rupprecht A, Haselgrübler T, Rankl C, Ebner A, Vater D, Pollheimer P, Pohl EE, Hinterdorfer P, Gruber HJ

Linking of Sensor Molecules with Amino Groups to Amino-Functionalized AFM Tips

Bioconjug Chem.; 22:1239-1248. (2011)

 


2010


Assem-Hilger E, Lanzenberger R, Savli M, Wadsak W, Mitterhauser M, Mien LK, Stögmann E, Baumgartner C, Kletter K, Asenbaum S.

Central serotonin 1A receptor binding in temporal lobe epilepsy: a [carbonyl-(11)C]WAY-100635 PET study

Epilepsy Behav.;19:467-73. (2010)

 

Bartova L, Berger A, Pezawas L.

Is there a personalized medicine for mood disorders?

Eur Arch Psychiatry Clin Neurosci. 2010 Nov;260 Suppl 2:S121-6. Epub 2010 Oct 19.

 

Bauer M, Karch R, Neumann F, Wagner CC, Kletter K, Müller M, Loescher W, Zeitlinger M, Langer O.

Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier.

J Cereb Blood Flow Metab. 2010 Mar;30(3):510-5. Epub 2009 Dec 16.

 

Bauer F, Kuntner C, Bankstahl JP, Wanek T, Bankstahl M, Stanek J, Mairinger S, Dörner B, Löscher W, Mueller M, Erker T, Langer O.

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor.

Bioorg Med Chem. 2010 Aug 1;18(15):5489-97. Epub 2010 Jun 22

 

Demel MA, Krämer O, Ettmayer P, Haaksma EEJ, Ecker GF.

Ensemble Rule-based classification of substrates of the human ABC-transporter ABCB1 using simple physicochemical descriptors.

Mol Inform 29, 233-242 (2010)

 

El-Kasaby A, Just H, Malle E, Stolt-Bergner PC, Sitte HH, Freissmuth M, Kudlacek O.

Mutations in the carboxyl terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.

J Biol Chem. 2010 Dec 10;285(50):39201-10. Epub 2010 Oct 2.

 

Ernst R, Kueppers P, Stindt J, Kuchler K, Schmitt L.

Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps - first come, first served?

FEBS J. 2010 Feb 1;277(3):540-9.

 

Frohner IE, Gregori C, Anrather D, Roitinger E, Schüller C, Ammerer G, Kuchler K.

Weak organic Acid stress triggers hyperphosphorylation of the yeast zinc-finger transcription factor war1 and dampens stress adaptation.

OMICS. 2010 Oct;14(5):575-86. Epub 2010 Aug 20.

 

Janneh O, Bray PG, Jones E, Wyen C, Chiba P, Back DJ, Khoo SH.

Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes.

J Antimicrob Chemother. 2010 May;65(5):906-16. Epub 2010 Mar 17.

 

Kasess CH, Stephan KE, Weissenbacher A, Pezawas L, Moser E, Windischberger C.

Multi-subject analyses with dynamic causal modeling.

Neuroimage.;49:3065-74. (2010)

 

Kienberger F, Zhu R, Rankl C, Gruber HJ, Blaas D, Hinterdorfer P.

Atomic force microscopy studies of human rhinovirus topology and molecular forces.

Methods Enzymol. 2010;475:515-39. doi: 10.1016/S0076-6879(10)75019-9.

Klepsch F, Ecker GF.

Impact of the recent mouse P-glycoprotein structure for structure-based ligand design.

Mol Inf 29, 276-286 (2010)

 

Klepsch F, Jabeen I, Chiba P, Ecker GF.

Pharmacoinformatic approaches to design natural product type ligands of ABC-transporters.

Curr Pharm Design 16, 1742-1752 (2010)

 

Klepsch F, Stockner T, Erker T, Müller M, Chiba P, Ecker GF.

Using structural and mechanistic information to design novel inhibitors/substrates of P-glycoprotein.

Curr Top Med Chem 10, 1769-1774 (2010)

 

Klepsch F, Ecker GF.

Impact of the recent mouse P-glycoprotein structure for structure-based ligand design.

Mol Inf 29, 276-286 (2010)

 

Kohut P, Wüstner D, Hronska L, Kuchler K, Hapala I, Valachovic M.

The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: Dehydroergosterol fluorescence study.

Biochem Biophys Res Commun. 2010 Nov 24. [Epub ahead of print]

 

Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, Karch R, Brauner R, Meier M, Ding X, Müller M, Löscher W, Langer O.

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

Eur J Nucl Med Mol Imaging. 2010 May;37(5):942-53. Epub 2009 Dec 17

 

Mairinger S, Langer O, Kuntner C, Wanek T, Bankstahl JP, Bankstahl M, Stanek J, Doerner B, Bauer F, Baumgartner C, Löscher W, Erker T, Müller M.

Synthesis and in vivo evaluation of the putative breast cancer resistance protein inhibitor [11C]methyl 4-((4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)amino-carbonyl)-2-(quinoline-2-carbonylamino)benzoate.

Nucl Med Biol. 2010 Jul;37(5):637-44. Epub 2010 Apr 8

 

Pezawas L, Meyer-Lindenberg A.

Imaging genetics: Progressing by leaps and bounds.

Neuroimage; 53:801-3. (2010)

 

Rabl U, Scharinger C, Müller M, Pezawas L.

Imaging genetics: Implications for research on variable antidepressant drug response.

Exp Rev Clin Pharmacol; 3:471–89. (2010)

 

Rabl U, Hartinger B, Pezawas L.

At a glance: The serotonin reuptake speed regulates the activity of cingulate cortex.

J. Neurol. Neurochir. Psychiatr.;11,84. (2010)

 

Sarker S, Weissensteiner R, Steiner I, Sitte HH, Ecker GF, Freissmuth M, Sucic S.

The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the Serotonin transporter.

Mol Pharmacol. 2010 Dec;78(6):1026-35. Epub 2010 Sep 9.

 

Scharinger C, Rabl U, Sitte HH, Pezawas L.

IImaging genetics of mood disorders.

Neuroimage 2010 Nov 15;53(3):810-21. Epub 2010 Feb 13.

 

Schwarzmüller T, Klein C, Valachovic M, Kuchler K.

Membrane transporters in pleiotropic drug resistance and stress response in yeast and fungal pathogens.

In Transporters as Drug Carriers: Structure, Function, Substrates (Eds Gerhard Ecker and Peter Chiba) WILEY-VCH, Weinheim, pp159-194, (2010).

 

Sitte HH, Freissmuth M.

The reverse operation of Na(+)/Cl(-)-coupled neurotransmitter transporters--why amphetamines take two to tango.

J Neurochem. 2010 Jan;112(2):340-55.

 

Schwarzmüller T, Klein C, Valachovic M, Kuchler K.

Membrane transporters in pleiotropic drug resistance and stress response in yeast and fungal pathogens.

In Transporters as Drug Carriers: Structure, Function, Substrates (Eds Gerhard Ecker and Peter Chiba) WILEY-VCH, Weinheim, pp159-194, (2010).

 

Sucic S, Dallinger S, Zdrazil B, Weissensteiner R, Jorgensen TN, Holy M, Kudlacek O, Seidel S, Cha JH, Gether U, Newman AH, Ecker GF, Freissmuth M, Sitte HH

The amino terminus of monoamine transporters is a lever required for the action of amphetamines.

J Biol Chem. 2010 Apr 2;285(14):10924-38. Epub 2010 Jan 29.

 

Wagner CC, Langer O.

Approaches using molecular imaging technology - use of PET in clinical microdose studies.

Adv Drug Deliv Rev. 2010 Sep 29.

 

 

Zhu R, Howorka S, Pröll J, Kienberger F, Preiner J, Hesse J, Ebner A, Pastushenko VP, Gruber HJ, Hinterdorfer P.

Nanomechanical recognition measurements of individual DNA molecules reveal epigenetic methylation patterns.

Nat Nanotechnol. 2010 Nov;5(11):788-91. doi: 10.1038/nnano.2010.212. Epub 2010 Oct 31.


2009


 

Bankstahl JP, Kuntner C, Abrahim A, Karch R, Stanek J, Wanek T, Wadsak W, Kletter K, Mueller M, Loescher W, Langer O.

Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood–Brain Barrier Studied with (R)-11C-Verapamil and PET

(doi: 10.2967/jnumed.108.051235)

 

Bauer M, Karch R, Neumann F, Abrahim A, Wagner CC, Kletter K, Müller M, Zeitlinger M, Langer O

Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET

(doi: 10.1007/s00228-009-0709-5) Eur J Clin Pharmacol

 

Demel MA, Kraemer O, Ettmayer P, Haaksma EE, Ecker GF.

Predicting ligand interactions with ABC transporters in ADME.

Chem Biodivers. 2009 Nov;6(11):1960-9. Review.

 

Dörner B, Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, Mairinger S, Löscher W, Müller M, Langer O*, Erker T

Synthesis and Small-Animal Positron Emission Tomography Evaluation of [11C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood-Brain Barrier

(doi: 10.1021/jm900940f)

 

Ecker GF, Chiba P

ABC-transporters – from target to antitarget.

In: Ecker GF, Chiba P (editors) “Transporters as Drug Carriers” from the series “Methods and Principles in Medicinal Chemistry”, Wiley-VCH, Weinheim (2009)

 

Ecker GF.

QSAR studies on ABC-transporter – how to deal with polyspecificity.

In: Ecker GF, Chiba P (editors) “Transporters as Drug Carriers” from the series “Methods and Principles in Medicinal Chemistry”, Wiley-VCH; Weinheim (2009)

 

Egaña LA, Cuevas RA, Baust TB, Parra LA, Leak RK, Hochendoner S, Peña K, Quiroz M, Hong WC, Dorostkar MM, Janz R, Sitte HH, Torres GE.

Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3.

J Neurosci. 2009 Apr 8;29(14):4592-604.

 

Maier S, Reiterer V, Ruggiero AM, Rothstein JD, Thomas S, Dahm R, Sitte HH, Farhan H.

GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation.

J Cell Mol Med., 2009

 

Pezawas L, Meyer-Lindenberg A

Genetically Driven Interactions in the Brain: Lessons from Depression

In: Mayer EA, Bushnell C, editors. Functional Pain Syndromes: Presentation and Pathophysiology. Washington, DC, USA: IASP Press;398-9.(2009)

 

Pezawas L, Weinberger DR

Molecular Genetics

In: Ingram RI, editor. The International Encyclopedia of Depression. Berlin, Vienna, New York: Springer;;396-9. (2009)

 

Pirker S, Gasser E, Czech T, Baumgartner C, Schuh E, Feucht M, Novak K, Zimprich F, Sperk G.

Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy.

Hippocampus.;19:1051-4. (2009)

 

Rockwell NC, Wolfger H, Kuchler K, Thorner J.

ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae.

J Membr Biol. 2009 May;229(1):27-52.

 

Sitte HH., Freissmuth M.

GAT1 UCSD-Nature Molecule Pages

UCSD Signalling Gateway (2009)(doi:10.1038/mp.a002759.01)

 

Stockner T, de Vries SJ, Bonvin AM, Ecker GF, Chiba P.

Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains.

FEBS J., 2009

 

Schlachter K, Gruber-Sedlmayr U, Stogmann E, Lausecker M, Hotzy C, Balzar J, Schuh E, Baumgartner C, Mueller JC, Illig T, Wichmann HE, Lichtner P, Meitinger T, Strom TM, Zimprich A, Zimprich F.

A splice site variant in the sodium channel gene SCN1A confers risk of febrile seizures

Neurology.;72:974-8. (2009)

 

Wagner CC, Bauer M, Karch R, Feurstein R, Kopp S, Chiba P, Kletter K, Loescher W, Mueller M, Zeitlinger M, Langer O

A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit P-glycoprotein at the Human Blood–Brain Barrier with (R)-11C-Verapamil and PET.

J Nucl Med. 2009 Dec;50(12):1954-61. doi: 10.2967/jnumed.109.063289. Epub 2009 Nov 12.

 

 

Zhu R, Ebner A, Kastner M, Preiner J, Howorka S, Hinterdorfer P.

Topography and recognition imaging of protein-patterned surfaces generated by AFM nanolithography.

Chemphyschem. 2009 Jul 13;10(9-10):1478-81. doi: 10.1002/cphc.200900245.


2008


 

Abrahim A, Luurtsema G, Bauer M, Karch R, Pataraia E, Joukhadar C, Kletter K, Lammertsma AA, Baumgartner C, Müller M, Langer O.

Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients

Eur J Nucl Med Mol Imaging.;35(1):116-23. (2008)

 

Bankstahl JP, Kuntner C, Abrahim A, Karch R, Stanek J, Wanek T, Wadsak W, Kletter K, Müller M, Löscher W, Langer O.

Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.

J Nucl Med., (2008)

 

Ernst R, Kueppers P, Klein CM, Schwarzmueller T, Kuchler K, Schmitt L.

A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5.

Proc Natl Acad Sci U S A., (2008)

 

Gregori C, Schüller C, Frohner IE, Ammerer G, Kuchler K.

Weak organic acids trigger conformational changes of the yeast transcription factor War1 in vivo to elicit stress adaptation.

J Biol Chem., (2008)

 

Jungwirth H, Ring J, Mayer T, Schauer A, Büttner S, Eisenberg T, Carmona-Gutierrez D, Kuchler K, Madeo F.

Loss of peroxisome function triggers necrosis.

FEBS Lett., (2008)

 

Korkhov VM, Milan-Lobo L, Zuber B, Farhan H, Schmid JA, Freissmuth M, Sitte HH.

Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies.

J Mol Biol., (2008)

 

Kasess CH, Windischberger C, Cunnington R, Lanzenberger R, Pezawas L, Moser E.

The suppressive influence of SMA on M1 in motor imagery revealed by fMRI and dynamic causal modeling

Neuroimage.;40:828-37. (2008)

 

Meiblitzer-Ruppitsch C, Vetterlein M, Stangl H, Maier S, Neumüller J, Freissmuth M, Pavelka M, Ellinger A.

Electron microscopic visualization of fluorescent signals in cellular compartments and organelles by means of DAB-photoconversion.

Histochem Cell Biol., (2008)

 

Reiterer V, Maier S, Sitte HH, Kriz A, Rüegg MA, Hauri HP, Freissmuth M, Farhan H.

Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting.

J Neurosci., (2008)

 

 

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